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Clinical Research

Clinical Research Papers

A New Technology to Determine Circadian Blood Pressure and Arterial Compliance Variations During Ambulatory Monitoring

Brinton TJ, Neutel JM, Walls ED, Chio S-S, Smith DHG, Franklin SS, Weber MA, UCI, Orange, CA, and Pulse Metric, Inc., San Diego, CA.

OBJECTIVE

To derive simultaneous blood pressure (BP) and arterial compliance (C, ml/mmHg) measurements during a 24-hour period and evaluate changing hemodynamics in circadian BP regulation.

METHODS

18 subjects, age 53± 3 years (9 treated hypertensives, 9 normotensives), underwent 24-hour ambulatory BP and C monitoring using the DynaPulse 5000A. Measurements were performed at 15 minute intervals during both day and night. The new non-invasive device utilizes a cuff sphygmomanomctcr to determine BP and C from analysis of the oscillometric pulsation signal. C measurements are derived at MAP (near-end systolic) in the cardiac cycle.

RESULTS

Average 24-hour blood pressure was 145/77 mmHg in hypertensives and 136/73 mmHg in normotensives. However, circadian BP variations had an inverse correlation with C in both groups. Interestingly, C had the strongest correlation with pulse pressure (PP) for each monitoring. The non-linear PP vs C relation was best fit by a power function with average correlation r = 0.78.

CONCLUSION

Results suggest that C and PP demonstrate a strong inverse non-linear relation. Therefore, circadian blood pressure regulation may be influenced by vascular function. Since hypertension may affect BP regulation, the ability to evaluate both BP and C should prove useful in both disease diagnosis and treatment.

*Presented at the Italian Society of Chronobiology Scientific Meetings, 1996.